Modeling OxLDL Epigenetic Innate Immune Training of Monocytes in Early Atherosclerotic Plaques


 Atherosclerotic cardiovascular disease (atherosclerosis) is the leading cause of death worldwide. While atherogenesis generally well understood, sustained inflammation seen in some rapidly developing plaques remains largely unexplained. Recent research epigenetics reports chromatin remodeling with significant pro-atherogenic effects human monocytes exposed to oxLDL. Data collected from isolated vitro suggests that epigenetic innate immune training may explain observed persistent inflammatory state, however, has yet quantify on early plaque dynamics. In present study, I employ a partial differential equation and agent based mathematical model describe key markers system “untrained” or “trained” monocytes. Time dependent solutions suggest oxLDL produces pronounced pro-inflammatory response which counts macrophages foam cells. These results provide further support for targeting epigenome treatment atherosclerosis.